I'm not. The same people who seemingly magically cared about Flock overnight will move onto something else within the year. There's always something new to be outraged over, Flock is just the flavor of the week.
I think this taps in to why big tech companies are unconcerned as well. How many of these people who oppose data centers have stopped utilizing their outputs? How many of these anti AI folks are using AI either at work or in their personal lives? It's just hot to hate AI right now.
I asked it to create a design system in Paper, and it actually did a fairly decent job when it wasn't getting network errors. I'd say it's much, much closer to good than bad.
Read "Building a new space coast" and I immediately wondered what our elected officials here in Florida must have felt when they saw that line. I'd love for SpaceX to greatly expand their presence here in Florida, but at the same time the coast is probably too built up here for SpaceX to have a facility like that unless they go into the panhandle.
>Guess they don't care about regular devs atm and are focused only on hardware sales.
Why would they want to target regular devs right now? If they sold to regular devs instead of enterprises, the complaint wouldn't be about model choice, it'd be about how expensive it.
Seriously, even as well paid as many devs are these are not machines that are affordable for personal use. Their market is people slapping down millions on frontier model training.
This is great news! I think people forget how anti-skin cancer protocols even as simple as applying suntan lotion weren't as popular as recent as 50-60 years ago. Lots of "sun children" of the 50s and 60s are now feeling the repercussions of only applying baby oil and are getting hit with lots of melanoma.
What’s funny is before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you.
Laura Ingalls Wilder of Little House fame (I mention this a lot as I read these to my children as an adult, and they’re a fascinating look at 1880s America) has lots of places where her mother says “put on your bonnet! Don’t get too much sun!”. We act like people in the past were ignorant but people in the 50s and 60s were just a very special type of arrogant, all of Chesterton’s fences were torn down during that time period.
They thought too much sun was bad for you because back then tanned skin was considering a mark of being poor and pale skin was a mark of being wealthy since rich people didn’t have to work outside.
They also had puritanical Victorian notions of modesty and covering up.
There was no knowledge linking sun exposure to cancer or negative health effects. People in the past indeed were ignorant on many things.
Or rather, linked to completely wrong negative health effects that were just “common knowledge” thus requiring no actual evidence like:
People with light skin should always wear a hat that fully covers the head/face in tropical/equatorial climates (okay, good so far) or else the powerful sun rays will penetrate the skull (?) causing brain damage that will make you go insane (!?!?)
Victorians may have inadvertently protected themselves against excess mortality due to melanomas with their pith helmets, but it’s pretty hard to argue they were actually “correct” with modern hindsight considering the entire chain of reasoning was wrong.
(For example, you see this in Kipling’s writing where he’ll randomly include an ominous case of some guy who forgot/lost his hat and promptly had to be committed to an insane asylum, as one does).
Unless you are albino (which is a large set of other problems) being in the sun all day will develop enough of a tan that you won't sunburn. There might be a problem in spring, but by summer time most people will have spent enough time outdoors that they wouldn't sunburn. I've always been the lightest person in town (a tie in Stockholm) and I can spend all day outside without any sunscreen and I won't burn on the parts of my body normally not covered (my arms), but other parts would burn in a few minutes (If I took off my hat or shirt...)
As someone from Britain with Scottish ancestry I don’t really tan at all. The melanin in my skin clumps in freckles, severely limiting its effectiveness at blocking UV. I can spend time outside in a t-shirt during the long summer evenings in Britain/Scandinavia but will burn during the midday sun. Living in California now the sun is stronger for longer so I just cover up.
San Francisco is at a southern European latitude. It’s a lot worse in the tropics.
I don't know about that. I'm a fairly tanned individual, but where I live, in Texas, if I spend all day in the sun, I'm getting sunburned bad everywhere.
That "if" makes me understand that spending all day in the sun is not something you normally do. I've been told by others who live in Texas that you can build up tolerance and spend all day in the sun.
Naturally darker skin does not automatically provide sunburn protection. It is spending time in the sun that adds the missing part that provide that protection. I don't know how this differs from dark skin, but I've seen it myself.
Note that my claims are only about sunburn. The article/topic is skin cancer which may well have different factors from sunburn.
Are you paying for my mid life crisis? Otherwise my boss expects me back in the office before I could build up the needed tolerance (I'm expecting this to take a month) such that I'd expect to spend all day in the sun without burning.
Black people who spend all their time indoors or covered up will get sunburned if they go outside. If that black person gradually increases their sun exposure they can (in a few weeks) reach the point where they can be outside without sunscreen and they will not get sun burned.
Note that I'm making no claims on how natural sunburn resistant affects skin cancer.
Increased melanin provides some protection against burns, but it doesn’t make you immune. There’s also the aspect of UV damage without burns, which is still harmful and is not affected by melanin levels.
that's his point. anyone can get sunburned, and almost anyone can prevent sunburn through gradual exposure. except albinos, who are especially susceptible.
melanin is also not the only factor in preventing sunburn/cancer. there are many repair pathways and genes, which are present to differing levels in various populations.
The same is true for me, a white person of northern European heritage. If I have a few weeks and time to work at building up a tan, I can get to the point where I won't burn. I did this during the pandemic when I was home all day. I would go out and lie in the sun, starting at 15 minutes, turn over, go another 15 minutes, and go back inside. Increased the time as my skin darkened. Felt nice, never burned.
This is an illusory statistic because "black people" isn't a real category. People who self-identify as "black" have a wide-range of skin tones. Even a moderate bit of brown completely eliminates the risk of sunburn. You can have two "black" parents and be lighter skinned than the average southern Italian.
I say this from experience. I am a black person who is not particularly dark skinned, and have only had the slightest sunburn once in my life, after I had been working in a field for 16 hours straight in full sun under clear sky detasseling corn. When I got back to camp, the back of my neck seemed slightly sensitive, which was unusual. It was fine the next morning, and never peeled at all. I did the same for 2 weeks, and this was the only time I felt this. This was the worst sunburn (if it was one) that I've gotten in 50 years of life. I've spent plenty of time outside, and plenty of time inside being a code monkey and never going outside. I've never worn sunscreen.
I've never met a black person as brown as a paper bag who ever got a sunburn, at least that I know of. My dad is pretty pale, I think I would have heard about it.
I’m overwhelming white ancestry but with some remnant traces of melanated ancestry (> 1%) and I tan very easily. I’ve been mistaken for hispanic or Black before during the summer. My mom is much darker than me.
We both get sunburns. My even darker grandmother got sunburns. My Black friends get sunburns. I am not sure that you are correctly correlating your experience with actual facts about the sunburn resistance offered by melanin.
As a counterexample, my bestie is "brown as a paper bag", and he was convinced he couldn't get a sunburn, up until he did.
Unrelated, he also swore he couldn't get poison ivy, until he literally rolled in it to prove it to me. I found the aftermath more amusing than he did.
This is silly.... most of the world didn't live in england.
All cultures (including mine), have a way to warn kids, or adults for not to stay too long in the sun.
From normal sunburn, to feeling light-headenes/fainting due to heat excaustion, etc.
In the winter was the opposite. (stay in the sun to get some sunlight and not get sick).
So, they knew, and had nothing to do with 'class'. Also, they knew some sun was good/beneficial, especially during the winter.
Pale beauty is a phenomenon across geography. What correlation a society works out is largely lost in the cycles of avoiding the sun being a relative luxury until you get expensive air travel.
Again... you are confusing second order effects, with the primary reason.
We have an old saying "te rafte pika e diellit", may you get a spot, sun spot, aka cancer from the Sun.
People knew excessive sun is unhealthy.... if you could you avoid it during the summer. It was not necessary to make you look 'rich'. Ability to avoid it, meant you were rich. And people wanted to be pale, because you look rich, that is a second order effect, that came because of the original reason (aka, too much sun is unhealthy).
The correlation looks right so all people who have rituals like telling their children not to look poor really understand and later communicate the truth? Is this true for religious stigmas related to food too?
I think you are retro analyzing and presuming individual intelligence because this collective result looks right to you. Really, some people understand some risks and many people who can follow taboos they can afford are not exactly sure what they would learn first hand and what part is superstition.
They were no dumber then than in 2026, but they fundamentally had much less access to information. How much do you trust the medical advice of an uneducated person in 2026?
"Hm, whom to trust, a person who went to university and follow-on education for nigh a decade, oorrrrrrrrrr.... something someone posted on Facebook that just so happens to confirm what my own ignorance told me was likeliest?"
I don't think that was because of UV exposure or anything related. Look at Bedouin tribes even today. They wrap up head to toe, man and woman and child alike, not to avoid tanning but because prolonged exposure to direct infrared will fry you like an egg.
I grew up in the same general region as Wilder, and we sought shade not to avoid sunburn. We were all chestnut brown by the end of summer anyway. It's because the direct sunlight on an August afternoon was brutally hot, and you wanted as little of it to hit your skin as possible.
> before the 50s and 60s everyone knew you should cover up and women wore bonnets. That too much sun was bad for you.
I'd say partly true, mostly false. As sibling comment mentions, much of this was driven by fashion and class etc. and not from some fundamental understanding of damaging UV exposure.
Furthermore there was research that was trendy at the time called "heliotherapy" [0] where all sorts of diseases were believed curable by sun exposure, including smallpox, TB, etc.
In retrospect, I wonder if there was a measurable effect on sun exposure creating vitamin D => immune system recovery, especially if the patient were otherwise not outside much?
Like, I doubt that fixing a vitamin D deficiency is going to cure you of smallpox or TB, but could imagine a path where it helped at least.
> We act like people in the past were ignorant but people in the 50s and 60s were just a very special type of arrogant,
I’d be curious to know if tetraethyllead in gasoline has anything to do with people from that time being cavalier about exposure to the sun, or if the science was just not there to make the connection between sun exposure and skin cancer.
We developed creams that stopped sunburn, but were still great at getting you cancer. A lot of the ads from 70s and 80s talked about how they stopped UVB but let the tanning UVA through! So yes, they didn't burn, but the long term cancer rates exploded, along with all the skin aging.
So it's not that they ignored the all knowledge. I blame most of it on the rather detrimental tech advancement. Like cigarettes with filters: now safer (except you can smoke more now, and the cancer risk is still a disaster)
technically UVB is much more tanning than UVA. UVA tans for a short amount of time. UVA penetrates much deeper into the skin though and has few benefits (UVB stimulates Vitamin D synthesis).
That's the right thing for the wrong reason, which can actually significantly forestall figuring out what's actually going on.
Scurvy is like that. They figured out that if you give sailors a ration of fresh fruit juice they don't get scurvy - this works because the fresh fruit juice has Vitamin C and Scurvy is just Vitamin C deficiency. But they didn't know why it worked - why would a cow, a mango, a lettuce, and indeed basically everything else have a chemical in it that humans can't synthesize ? That's crazy. Except, nope, that's really what's going on. At some point an ancestor deleted the synthesis pathway for this chemical, their offspring weren't bothered because fresh literally everything has the chemical anyway, so the deletion stuck around.
At the same time ships get quite a lot faster, travel across the Atlantic is now rapid enough that even if you deliberately abstained from Vitamin C you wouldn't get scurvy, your body hoards many chemicals it needs (a few must be made "fresh" but most can be hoarded) and only develops issues when the hoarded ascorbic acid is exhausted after a few weeks. But they don't know that, and so when they swap a working solution (store fruit, squeeze the juice out, drink fresh juice) for a non-working solution (squeeze the juice, preserve that, drink preserved juice) the apparent results do not change.
Until they do something more extreme. Go to Antarctica, which is incredibly hostile to life anyway, and then stay there for months. Despite your magic preserved fruit juice you get scurvy. The juice wasn't magic, and eventually you will figure out it was the freshness which was magic and from there that there really is a chemical found in cows, mango, lettuce and basically everything alive which we cannot synthesize. Ascorbic acid, Vitamin C.
In many places covering up is just not enough because of Rayleigh scattering. I don't think this vaccine eliminates need for sunscreen. You'd still feel extremely uncomfortable/pain after 15 minutes in places like Australia even if you don't get melanoma.
+1. Also, just to call out, it doesn't need to be _warm_ for you to need sunblock. Even when it's cooler / cloudier out there you can still get skin damage. Look for UV rating rather than temperature. Conversely, it being hot doesn't imply high-UV either.
I didn't know about the UV index or what it meant until like three years ago. It blows my mind I went that long without understanding. It was actually wonderful to learn that I could just see if I needed sunblock based on a 0-10 scale.
We never wore sunscreen as kids because we didn't burn. I probably have had three sunburns in my life. Learned once I became an adult that that wasn't sound logic...
I think the Apple Watch or the Weather app or something finally taught me UV index about the same time. Has this information always been readily available? Similarly mind blown about it.
This was my experience. Years ago I travelled to New Zealand in what would be their spring time. We stayed in Wanaka but also travelled around Twizel, Tekapo etc.
Although it was pretty sunny with clear blue skies, the air temperature was fairly chilly (shirt, jumper and fleece cold - and I'm Scottish so used to cold weather) and I started to burn. I was warned about this, and the probability of high UV exposure at altitude by the locals and family, and was advised to apply a high factor sunblock whilst roaming around the higher elevations of New Zealand's South Island, which I did.
I got the worst sunburn of my life while skiing in Colorado. I wasn’t wearing goggles or anything on my face, and the sun plus the reflection off the snow was brutal. I didn’t notice it when I was out there, but the next morning I wasn’t able to open my eyes. Lesson learned.
I’ve always wondered about this. I have fair skin, and I tend to burn somewhat easily in very sunny environments like the beach.
However, I’ve never gotten so much as a whisper of sunburn / suntan / anything on an actually cloudy day where sun wasn’t hitting me directly. Is the damage a different type that’s imperceptible? Or is this a public health comms strategy where they assume people will see a single cloud in the sky and decide it’s fine to skip sunscreen, so they talk about how you should slather yourself with sunscreen 24/7, even if the sun is obscured?
I think the point is just about temperature. I've experienced this out on lakes in the northern US for example. It's sunny but not like a tropical beach, and maybe even a little chilly. But you'll definitely get burnt without sunscreen
People who are new to skiing/snowboarding are often surprised that their faces get sunburned, because of course it's cold and so how could they get burned
My mother always covered up and always made us kids cover up. She still died of melanoma. Sun may increase the risk, but sun cream doesn't make it impossible. Cancer has no friends.
Well done to the drug researchers. I have my fingers crossed someone else gets to avoid this
skin grows/regenerates at a rapid pace, which means mutations (mistakes in DNA replication) are naturally likely to happen there than in slow-growing tissue. skin cells and the immune system are constantly self-surveying and nipping these in the buds, under normal conditions. but there are things that can affect this process.
a recent study of 2 million people in ontario showed that both high-sun and low-sun exposed people had higher risk of melanoma than people with moderate exposure.
another explanation is that as much as you can try to cover up, occasionally you may slip up, and going from extreme low-exposure to intense sun is especially bad, because your repair pathways are not primed, skin is untanned, etc..
in conclusion, extreme low or high sun exposure is bad. at the beginning of the summer you should gradually exposure yourself, and then exposure yourself daily but not overly, for the rest of the year.
there is also that anything that blocks UV (sunscreen, windows, etc) by definition blocks UVB first and then UVA, and UVA is the one that penetrates most deeply and has few benefits
> Cutaneous melanoma (CM) accounted for around 331,700 cancer cases globally in 2022
> An estimated 267,353 (95% uncertainty intervals [UI]: 242,818, 278,638) CM cases were UVR attributable globally in 2022
UVR = Ultraviolet radiation
Cutaneous melanoma (CM) is the vast majority of melanoma cases in the US at least:
> The percentages of melanomas that were cutaneous, ocular, mucosal, and unknown primaries were 91.2%, 5.2%, 1.3%, and 2.2%, from https://pubmed.ncbi.nlm.nih.gov/9781962/
tl;dr ~80% of Cutaneous melanoma cases are attributable to UV exposure.
Please be careful and charitable in reading others' words, especially as they relate to scientific topics.
OP did not say that melanoma has no sun exposure risk but that it is lower than the risks associated with other cutaneous cancers (e.g., SCC and BCC) and it would seem that's true based on the very short search I performed.
Yes, but OP said that in response to a comment attributing melanoma to sun exposure, in a conversation where nobody had brought up SCC or BCC. It's still a misleading comment, in my opinion.
> Yes, but OP said that in response to a comment attributing melanoma to sun exposure, in a conversation where nobody had brought up SCC or BCC.
In a thread about a trial for a melanoma drug, which has nothing to do with the discussion of sunscreen. Sunscreen was brought up because it is a culture-war topic, the fact that melanomas are not as associated with sun exposure was brought up as the standard opposite-side reply to a culture-war topic.
Clearly your unrelated accusation was brought up to silence the other side and accuse them of dishonesty. Your follow-up is to accuse them of some conversational violation (mentioning something that wasn't brought up) which doesn't exist.
It's fine to see debate, but this is not debate. At most, consistent daily sunscreen use is associated with a 30-50% reduction in melanoma, and some of the ingredients in US sunscreens are themselves associated with cancer.
What would be helpful is a link to a study showing a general reduction in melanomas during a general increase in the use of sunscreen. I'd be able to point that out to friends who questioned me about the efficacy of using it.
edit: that one sentence reply is already trying to snowball into a pile on. Now to mention this fact has become "bizarre." Can't wait until it becomes "unhinged."
I think the problem is that it takes 30 years for the effects to start showing.
This data [1] shows incidence of melanoma by the age of 30 dropping by half in Australia, presumably as a result of a sun safety campaign that started in the late 80s (not just encouraging sunscreen but also more shade, hats, covering up, etc.). Yet melanoma rates here in general increase but it’s more and more skewed towards the older.
You're confusing me with u/addisonl. Please check usernames before accusing people of trying to "silence the other side."
To quote a blog post I wrote on why we can be confident sun exposure causes cancer: "Green et al. (2011) conducted a 10-year study (n=1621) in Nambour, a town in Queensland, Australia. Participants were randomly assigned to daily or discretionary sunscreen application. After 10 years, 11 melanomas were found in the daily group and 22 in the discretionary group."
But you should read the full post for more context on why we have much better data than randomized controlled trials, and why correlation studies on this subject are nearly useless due to the impossibility of finding reliable proxy variables: https://hedonicescalator.substack.com/p/contra-byrnes-on-uv-...
Saying "some of the ingredients in US sunscreens are themselves associated with cancer" is meaningless without more specificity. As the meme goes, this HackerNews comment is known to the state of California to cause cancer: the bar for something to be "associated with cancer" is incredibly low. Are there any particular chemicals or chemical classes you were worried about?
And I will remind you that, in contrast, we are 100% sure that sunlight causes cancer. We know exactly what kinds of DNA damage it creates (chiefly cyclobutane pyrimidine dimers, which I discuss in my blog post) and we can find cancer-causing mutations in melanoma samples directly downstream of that damage (C->T mutations, for example, ones that disable the key p53 tumor suppressor gene). We know how this shit works! Are there some sunscreen formulas that might be dangerous? Possibly, I don't have them all memorized, but the solution is to find a different brand... not to instead expose yourself to one of the best-studied carcinogens around.
>Clearly your unrelated accusation was brought up to silence the other side and accuse them of dishonesty. Your follow-up is to accuse them of some conversational violation (mentioning something that wasn't brought up) which doesn't exist.
the comment you are replying to is HedonicEscal8r's first comment in this comment chain.
>that one sentence reply is already trying to snowball into a pile on
no... it is correcting your comment that is accusing HedonicEscal8r of having multiple comments in this chain. HedonicEscal8r was not the one to make the comment that you describe as an "unrelated accusation" to "silence the other side".
common courtesy would be to say "oops, i didn't read the usernames, my bad" instead of accusing someone else entirely of "trying to snowball into a pile on" for calling you out on the mistake.
pessimizer misattributes a comment to someone who didn't write it. i mention it, get accused of "piling on", and then get downvoted. hn can be so fucking weird.
By pointing out that it is true using a reference?
> the reply
The reply misunderstood the first comment and went on to discuss something a)interesting but b) not germane to whether melanoma is the skin cancer with the highest sun exposure risk.
I have no idea what you mean by context as this small discussion is quite self-contained. Think of this as making sure everyone realizes two homophones actually are distinct words.
No this is insane news, the world is crazy and dumb. Must be all these LLMs. Stock up more than 150%, based on totally unpublished data and an X post...
- The flashy 49% figures are from the old 157 only patient Phase 2, not this Phase 3 trial. The phase 2 was open label, had only 50 controls, and its randomization was disrupted. Meaning 9 patients were reassigned and the final 37 were no longer randomized.
Its primary RFS result was p=0.053 two-sided, with the 95% CI crossing 1. It also used an unusually permissive one-sided alpha of 0.10, and much of the later "confirmation" is just longer follow up of those same 157 patients...
- This phase 3 news so far is nothing more than a press release. They have not published hazard ratio, or confidence interval, their event counts or survival curves.
- They met the endpoint as used in the press release means nothing, until they publish the actual 3 data, so my money is at the end this will be a kind of marginal effect that researchers will struggle to reproduce for years
Another type of study that will take 2 to 3 years to validate or dismiss, in the meanwhile stock is up 150%....
150% increase is because it started from a low point. Moderna's stock lost 94% value after Covid. Stock price speaks to investors' enthusiasm, there is no algorithm.
> This phase 3 news so far is nothing more than a press release.
Can you find a case where a press release after phase 3 was later proven wrong? They do have the data, and most likely the data is positive. They're talking about FDA's approval as soon as late 2027, which is fairly soon.
Do you know what would be more dramatic than stock gaining 150%? that'd be the stock crashing if the press release turned out to be wrong. Follow the money if you are skeptical. See who's selling.
> The flashy 49% figures are from the old 157 only patient Phase 2, not this Phase 3 trial.
There are 1,100 patients in phase 3. More evidence that they're pretty confident.
>> Can you find a case where a press release after phase 3 was later proven wrong?
Galera Therapeutics, Actimmune, leronlimab, roxadustat, tivozanib, aducanumab, tebipenem are all examples of Phase 3 massive failures.
>> This is great news.
Looking forward to the stock market reacting with the same level of due diligence show here, when the actual science data is published...in a still not announced distant future... :-)
the stock is up 150% because if Moderna has indeed cured cancer, the stock is worth many magnitudes more than that. It's presumably based on the probability this report is indeed as promising as it is at face value. If Moderna had announced "we are 100% sure cancer is cured" the stock would've gone up much more
These are patients who had melanoma surgically removed, and IF the unpublished data of phase 3 turn out to be true... you are looking at having improved survival rates after 2 to 3 years on 5 to 10% plus of the patients. That is ALL this still unknown announcement MIGHT mean.
For what it's worth, AFAICT Moderna and other such high-tech biopharma stocks are way too sensitive to the news cycle and not nearly enough to scientific fundamentals, so I took the opportunity of having it up 150% to sell mine off.
> Cutaneous melanoma (CM) accounted for around 331,700 cancer cases globally in 2022
> An estimated 267,353 (95% uncertainty intervals [UI]: 242,818, 278,638) CM cases were UVR attributable globally in 2022
UVR = Ultraviolet radiation
Cutaneous melanoma (CM) is the vast majority of melanoma cases in the US at least:
> The percentages of melanomas that were cutaneous, ocular, mucosal, and unknown primaries were 91.2%, 5.2%, 1.3%, and 2.2%,
from https://pubmed.ncbi.nlm.nih.gov/9781962/
Your reading comprehension is way off. The article says "Each year in Australia, up to 420 people are diagnosed with acral or mucosal melanomas. They affect people of all ethnic backgrounds, and are the most common forms of melanoma in people with very dark skin."
That is a discussion of specific subtypes of melanoma. You've turned that into a general statement about melanoma:
> not all skin cancers are caused by sun exposure, and this is more true for Melenoma which occur both more frequently in darker skinned people and in place where there is little sun exposure.
These are "Two rare ... forms of melanoma" not "melanoma as a whole." The article does not say melanoma as a whole is more frequent in darker-skinned people and in places with little sun exposure. Those two subtypes are.
> BCC ... can cause significant local tissue damage if left untreated. Most cases are linked to chronic sun exposure, especially in fair-skinned individuals.
> While it often remains localized at first, SCC can invade deeper tissues and, in some cases, metastasize to lymph nodes or other organs. Risk factors include cumulative sun exposure, a history of sunburns, and immunosuppression.
> While not all skin cancers can be prevented, effective sun protection and healthy habits can greatly reduce your risk for basal cell carcinoma, squamous cell carcinoma, and melanoma.
That does not support "most skin cancers are not a big deal"
"Whilst some studies reported an association with improved survival ... others did not find any significant association, and some even reported worse outcomes in patients whose tumors showed regression"
You seem to have read this as "melanoma just goes away and the problem is gone" rather than "the primary tumor can recede, and in that case survival odds are somewhat better by a few percentage points (but actually worse for Stage III patients!)"
"Melanoma is one of the deadliest forms of skin cancer, with more than 330,000 new cases diagnosed worldwide in 2022."
Saying melanoma is the deadliest forms of skin cancer is not revealing anything and is a scare tactic. In 2022, there were approximately 60,000 deaths worldwide due to melanoma. A rare cancer with 18% death rate is not high compared to the others. The deadliest cancers include lung cancer, pancreatic cancer, liver cancer, colorectal cancer, and breast cancer. These cancers have the lowest survival rates and account for a significant number of cancer-related deaths.
But I will wait for the upcoming complications and the worse 5 year all cause mortality rate in these patients.
Question for you: what is the goal of these comments? What is it would you like people to do or think differently after reading what you've written?
I'll go first: my hope is that someone who has read what I've written will be more likely to take seriously something suspicious they see on their skin rather than ignore it as unimportant, and be more inclined to take seriously protection from sun exposure when possible
My goal is to 1) not reward these companies by over inflating phase 3 clinical trial outcomes and 2) to not fear a skin cancer diagnosis and 3) not live your life in a bubble while polluting the world with sunscreen.
Sun exposure does not cause skin cancer. It only increases the risk of skin cancer in some people. Look at the ROI on people's behavior and it makes no sense. Are we actually causing more damage by using all this sunscreen and the plastic bottles it comes in and lowering everyone's vitamin D levels?
Sunscreen was widely used in the 70's and skin cancer rates keep going up. It's useless.
There are truths in there, but you seem to be looking only for evidence that supports your beliefs (and misreading evidence against your beliefs) instead of tailoring your beliefs based on evidence. Additionally you make blanket, definitive assertions like "sun exposure does not cause skin cancer" which no one should be listening to
Multiple things can be true at the same time:
1. Skin cancer can be successfully treated if found and removed early
2. Vitamin D is healthy and necessary, but at the same time too much sun exposure is harmful. That harm depends on different factors (like skin tone)
3. Some kinds of sunscreen might be problematic or bad for the environment, but there are different kinds of sunscreen (mineral-based, reef-safe)
4. There are multiple ways to mitigate sun exposure, not just sunscreen (avoid peak UV times, wear sun-protective clothing). Mitigation doesn't mean "complete avoidance"
5. Sun exposure is not the only cause of skin cancer, but it is a cause of skin cancer and a common one at that
I did not say that the sun does not increase the risk of skin cancer. I did say it does not cause skin cancer. Do you understand the distinction I’m making? “Cause” can only be determined when the event has already happened. And even in the case of the sun causing someone’s skin cancer, it is not the only variable.
Why, it seems like the supply is limited by the ability to provide, and the demand is limited by market alienation.
They raise their prices too high, a lot of customers will still buy but be unhappy about it, it's burning goodwill for money. If they drop their prices too low they have overwhelming demand.
They could be making money hand over fist for all we know. We don't really know how much compute is being used, nor how much it cost them.
I’m curious about that too. Claude Design feels (and from the blog post) sounds like the typical IC passion project that got just polished enough for a “beta” (in the sense of gauging customer interest, not commitment to release).
If someone with clout at Anthropic takes it up as a champion and pushes it into the portfolio of apps at the importance of Claude code, it could be an amazing product, eventually a threat to Adobe, Lovable, Canva market share. It needs a better direct editing layer like 2-way figma sync, so you’re not stuck only prompting for every small adjustment. It could really use smart routing of image generation requests to a nano-banana level image generation model for the images that get poured into the ui mockups (so you don’t need to round trip to external sources by hand). And of course, like all modern LLMs doing visual work, it lacks “taste” if not given extensive examples during prompting.
Right now it feels like a fun proof of concept that could be killed at any time ala Google’s many “I got my PM promoted at launch and then was promptly abandoned” projects.
reply